One of the fundamental variables in preclinical biomedical research is sex: whether a cell, tissue, or animal is female or male. Biological sex is an important consideration for this research that underlies drug development, clinical trials, and prevention approaches.
The NIH Office of Research on Women's Health talked with some of the leading experts on studying sex to strengthen science. Hear what they have to say about how to take sex into account in preclinical research.
Dr. Gillian Einstein: Importance of Sex as a Basic Biological Variable in Preclinical Research
Dr. Arthur Arnold: Understanding Disease in Males and Females
Dr. Larry Cahill: Challenging Assumptions About Sex in Preclinical Research
Dr. Londa Schiebinger: Understanding Gender in Research
October 20, 2014, Workshop
Learn how to incorporate sex to strengthen scientific design from leaders in the field through this recorded full-day meeting hosted by ORWH. Read the workshop summary (PDF).
Learn more about the importance of reproducibility in biomedical research, the concept of including male and female subjects in studies, and the impact of including or not including sex as a basic biological variable.
Learn about practical methods to integrate the biological variable sex into research projects and cultivating a culture of "Sex Matters" across multiple disciplines. This video concludes with recommendations and highlights.
The NIH Record, November 7, 2014
Females and Males: Same and Different? NIH Workshop Explores Question
How do you incorporate sex as a variable in research with animals and cells? This question was the focus of an October 20 workshop hosted by ORWH. The workshop was designed to help scientists understand why sex in preclinical research is important, as well as to provide practical guidance on experimental approaches.