The Specialized Centers of Research Excellence (SCORE) on Sex Differences program is a signature program of the Office of Research on Women’s Health (ORWH).

Each SCORE program serves as a national resource for translational research, at multiple levels of analysis, to identify the role of biological sex differences on the health of women. These NIH-supported Centers of Excellence are vital hubs for research on sex and gender that also provide pilot funding, training, and education. SCORE investigators provide leadership in the development and promotion of standards and policies for the consideration of sex as a biological variable (SABV) and sex differences in biomedical research. Identifying the contributions of biological sex can assist in understanding the diversity of health outcomes and how this knowledge can be applied to the development of the next generation of interventions and medical treatments leading to improvements in women's health.
The current SCORE U54 program leverages over 15 years of our prior investment to create a disease-agnostic research program focused on sex differences and major medical conditions affecting women in the U.S. The former Specialized Centers of Research (SCOR) P50 program funded established scientists at centers across the country, with support from our NIH Institute and Center (IC) partners. Basic, clinical, and translational research approaches led to seminal contributions to the study of sex differences related to women’s health. The current ORWH SCORE program remains the only NIH centers program supporting disease-agnostic research on sex differences.

ORWH published the Specialized Centers of Research Excellence (SCORE) on Sex Differences (U54 Clinical Trial Optional) request for applications (RFA), RFA-OD-18-004, in fiscal year (FY) 2018 and funded six new awards. The 2018 RFA was reissued in FY 2019 (RFA-OD-19-013) to support additional centers. Each SCORE program has three highly integrated, synergistic research projects and an administrative core. The Career Enhancement Core is a new feature of the program whose goal is to support pilot research and train the next generation of scientists in the study of sex differences. As NIH-supported Centers of Excellence, the SCORE program’s centers provide leadership and serve as a resource in the development and promotion of standards and policies for the consideration of sex differences in biomedical research.

For more information about the SCORE program, please contact

SCORE Director: Jennifer Sullivan, Ph.D. 
Grant: U54HL169191 
Title: Improving Awareness of Women with Hypertension: ROAR (Rural, Obese, At Risk)

OVERVIEW: About 19 million deaths were attributed to cardiovascular disease (CVD) globally in 2020, an increase of ~20% from 2010; heart disease remains the leading cause of death for men and women in the United States. Hypertension is a major modifiable risk factor for CVD, and it has been suggested that eliminating hypertension would reduce CVD mortality by 30.4% in men and 38.0% in women. Although young women are considered “protected” from hypertension and the associated cardiovascular (CV) risk relative to age-matched men, the elimination of hypertension is projected to have a larger impact on CVD mortality in women. Importantly, the highest risk of death from hypertension is in the U.S. rural South, and specific subsets of women are particularly vulnerable to developing hypertension and CVD, including Black women. A critical barrier to limiting premature death from CVD is lack of awareness surrounding the risks of CVD. Our overall goal is to transform academic and community understanding of sex as a biological variable (SABV) in the consideration of hypertension. We will achieve this goal through rigorous research, creation and dissemination of innovative educational content, development of strategic partnerships, and enhanced community engagement in the Southeast U.S.  


Research is needed to advance our understanding of sex-specific mechanisms that control blood pressure (BP) to limit CV risk. The research projects are designed to improve scientific knowledge regarding the mechanisms controlling BP in (1) response to a high-fat diet and increases in obesity in males and females and (2) the role of autoimmunity in promoting hypertension and CV risk. All three projects include both preclinical and clinical experiments to address important gaps in our understanding of SABV in CVD.

  • Research Project 1: Basic Science and Clinical  
    Lead: Jennifer Sullivan, Ph.D. 

    Compared with age-matched men, young women are protected from hypertension and end organ damage. Yet, increasing epidemiological evidence suggests that this protection is compromised by chronic consumption of saturated fat. This project will determine whether activation and recruitment of immune cells in response to a chronic high-fat diet abolishes CV protection in females and will explore the mechanisms mediating increases in BP.  
  • Research Project 2: Basic Science and Clinical 
    Lead: Erin Taylor, Ph.D. 

    Systemic lupus erythematosus (SLE) disproportionately affects young women and markedly increases the prevalence of hypertension, and ultimately CV and renal disease, which are major causes of mortality in both this population and the U.S. Clinical data indicate that rates of obesity are increased in patients with SLE, and even in the absence of an overweight or obese body-mass index (BMI), patients with SLE have altered fat deposition and increased visceral adiposity compared to BMI-matched controls. This project will determine whether obesity in SLE leads to excess adipose tissue inflammation and elevated leptin levels that both promote B and T cell dysfunction, leading to disease pathogenesis and progression.  
  • Research Project 3: Basic Science and Clinical 
    Lead: Michael Ryan, Ph.D. 

    As noted above, SLE increases the prevalence of hypertension, and ultimately CV and renal disease; yet the mechanisms underlying the prevalent hypertension remain unclear. This project will determine whether a feedforward mechanism drives the generation of renal reactive oxygen species (ROS) during SLE, leading to impaired renal vascular function and increased tubular sodium reabsorption. This cycle involves the presence of neutrophil extracellular traps (NETs) that increase cell stress signals including high-mobility group protein 1 (HMGB1), TLR4 mediated mitochondrial dysfunction, and ROS production.  

Lead: Daria Ilatovskaya, Ph.D.

The Career Enhancement Core will work to (1) develop a foundation for long-term relationships among the research, medical, and lay communities in Georgia, Mississippi, and South Carolina and (2) bring greater awareness to the risk of CVD in women and the consideration of SABV in the control of hypertension through education, mentorship, strategic partnerships, and training of community-engaged researchers. The CEC will develop and implement several programs and tools to increase awareness of the risks associated with CVD and uncontrolled hypertension, and will increase interest in the study of SABV. Such activities will include SABV Workshop for Researchers, SABV Mentoring Academy, training of undergraduate and medical students in how to perform SABV research, mini-sabbaticals for pre- and postdoctoral scholars to gain training in SABV-related techniques, pilot grants from early career investigators, outreach into local schools and colleges to increase awareness and promote SABV research opportunities, community engagement, a qualitative needs assessment to identify barriers to seeking/obtaining CV health care among at-risk women, a dedicated medical illustrator to develop educational materials on CVD across the health span of women, and a Blood Pressure Checks for Women campaign that will place BP monitoring equipment in nail and hair salons in Augusta and Athens, Ga., Columbia, S.C., and Jackson, Miss., to empower women to monitor their BP.  

Leads: Jennifer Sullivan, Ph.D. & Michael Ryan, Ph.D.

The Leadership Administrative Core will provide vital support for all ROAR programmatic activities, ROAR Leadership and project investigators, faculty, and staff to ensure program success. This support will include (1) providing direction, oversight, support, and assessment of the entire program including the three research projects and the Career Enhancement Core, (2) coordinate communication and collaboration across the three ROAR institutions, and (3) work with the SCORE Consortium to maximize our impact, expand opportunities for trainees, and promote new collaborations in SABV in CVD. 

SCORE Directors: Hadine Joffe, M.D., M.Sc.
Grant: U54AG062322
Title: Brigham/Harvard Center for Reproductive Outcomes of Stress and Aging (ROSA)

OVERVIEW: Older women experience dramatic changes in the hypothalamic-pituitary-gonadal (HPG) axis and female reproductive hormones, producing vasomotor symptoms (VMS), sleep problems, cognitive changes, and cardiometabolic risks, which increase susceptibility to cardiovascular disease (CVD) and dementia. VMS occur in 85% of women and persist in one-third for 10+ years after menopause, potentially leading to prolonged disruption of quality of life, sleep disturbance, cardiometabolic risk, and extended VMS treatment, conferring further risk for CVD and dementia. Such health outcomes may also be influenced by stress exposures across the lifespan and during pregnancy, which may exert their effects through neural mechanisms. The Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS) SCORE is advancing our understanding of stress exposures and neural regulation of reproductive aging health outcomes, and catalyzing growth of translational women’s health and sex-differences research in aging women. We are pursuing novel translational science through three Projects.


  • Research Project 1: Clinical Science
    Leads: Hadine Joffe, M.D., M.Sc., & Pamela Mahon, Ph.D.

    This project is defining evoked stress responsivity, stress-related activation of neural networks on functional brain imaging, and GABA concentrations as markers of VMS occurrence and persistence, including compounding effects of poor sleep and stress exposures.
  • Research Project 2: Population Science
    Leads: Emily Oken, M.D., M.P.H., & Jorge Chavarro, M.D., M.S., Sc.D.

    This project is determining whether perimenopausal women with higher exposure to social stressors across the lifespan and physiological stressors across pregnancy have greater cardiometabolic risk and sleep-related, cognition-related, and neuropsychiatric symptoms.
  • Research Project 3: Basic Science
    Leads: Ursula Kaiser, M.D., & Victor Navarro, Ph.D.

    This project is characterizing the role of kisspeptin, neurokinin, and dynorphin (KNDy) neurons and upstream GABAergic neurons in mediating the effects of stress and corticosteroids on the HPG axis, VMS, and sleep disturbances in a rodent model. These scientific efforts receive critical support from the site’s cores.

Leads: Kathryn Rexrode, M.D., M.P.H., & Janet Rick-Edwards, M.P.H., Sc.D.

This core is promoting early-career investigators interested in sex differences researchers by supporting scholars, pilot projects, travel exchange fellowships, and a robust educational program.

Lead: Elizbeth Klerman, M.D., Ph.D.

This core is extending the research’s scientific impact by investigating sleep outcomes in humans and rodents. 

Leads: Hadine Joffe, M.D., M.Sc., & JoAnn Manson, M.D., M.P.H., Dr.PH.

This core provides scientific and administrative oversight and engages across the SCORE Consortium. Building on existing, fruitful collaborations, this outstanding interdisciplinary team of investigators—leaders in women’s health, sleep medicine, neuroimaging, neuroendocrinology, stress science, cognition, cardiometabolic risk, and reproductive epidemiology—is leveraging robust resources at the Connors Center for Women’s Health and Gender Biology and across synergistic women’s health and sleep programs at BWH.

SCORE Directors: Noel Bairey Merz, M.D., & Susan Cheng, M.D., M.P.H., M.M.Sc.
Grant: U54AG065141
Title: The Microvascular Aging and Eicosanoids - Women’s Evaluation of Systemic Aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence

OVERVIEW: The Cedars-Sinai Medical Center (CSMC) SCORE Program proposes that sexual dimorphism in both local and systemic eicosanoid variation contributes to sex differences in microvascular dysfunction and, in turn, to sex differences in age-related multi-organ disease. Motivated by MAE-WEST’s early findings and the need to understand the determinants and drivers of sex differences in age-related disease outcomes, the goal is to form a robust and sustainable structure of academic activities centered on systematically interrogating sex differences in the relationships among eicosanoids, microvascular dysfunction, and age-related end-organ disease, with an initial focus on the microvascular aging effects on brain, heart, and kidney function. The overarching objective of MAE-WEST is to enhance our understanding of sex differences in microvascular and chronic multi-organ diseases and, in turn, enable effective interventions through interdisciplinary science, education, and advocacy.


The three well-integrated translational research projects will aim to advance the understanding of sex-specific molecular drivers of chronic microvascular and end-organ disease.

  • Research Project 1: Population Science
    Lead: Susan Cheng, M.D., M.P.H., M.M.Sc.
    Co-Investigators: Priya Palta, Ph.D., M.H.S., & Eugene Rhee, M.D.

    The goal of Project 1 is to examine longitudinal variation in circulating eicosanoid levels in relation to age-related alterations in microvascular function in end-organ (cardiovascular, neurocognitive, renal) disease traits in large-community cohorts.
  • Research Project 2: Clinical Science
    Leads: Noel Bairey Merz, M.D.
    Co-Investigators: Chrisandra Shufelt, M.D., Janet Wei, M.D., Carl Pepine, M.D., Eileen Handberg, Ph.D., ARNP, Michael Nelson, Ph.D., M.S., & Jeffrey Wertheimer, Ph.D.

    The goal of Project 2 is to prospectively enroll and deeply phenotype a cohort of women and men to assess the relation of eicosanoids with organ-specific and global burden of microvascular disease, as well as their response to a trial of intensive medical therapy with Food and Drug Administration–approved agents (statins and ACEIs/ARBs).
  • Research Project 3: Basic Science
    Lead: John Shyy, Ph.D.
    Co-Investigator: Sonia Sharma, Ph.D.

    The goal of Project 3 is to study the mechanistic role of sex-specific eicosanoid signaling on human endothelial cell function and on microvascular function in experimental models of organ-specific disease as well as whole organism aging.


Lead: Noel Bairey Merz, M.D.
Co-Investigators: Mariko Ishimori, M.D., Joshua Pevnick, M.D., & Denis Magoffin, M.D.

The Cedars-Sinai Career Enhancement Core provides mentoring from a diverse body of high-caliber faculty mentors who bring scientific expertise and career mentoring experience from across multiple fields and institutions. The core also facilitates all trainee projects using services and resources available from across an inter-institutional collaborative. The core centers all activities on the overarching goal of developing the next generation of translational investigators equipped to lead the discovery and implementation of interventions aimed at eliminating sex disparities in health, in sync with the goals of both this SCORE site and the overarching mission of the SCORE program as a whole. The core also serves as a hub for education in and dissemination of innovative translational research methods, results, and best practices for scientific and clinical audiences at large.


Type: Biostatistics & Informatics Core
Co-Leads: Susan Cheng, M.D., M.P.H., M.M.Sc., & Andre Rogatko, Ph.D.
Co-Investigator: Marcio Diniz, Ph.D.

The Biostatistical & Bioinformatics Core provides dedicated end-to-end support and resources for efficiently managing and analyzing eicosanoids data generated from diverse human, animal, and cell biospecimens in relation to microvascular aging traits across the Cedars-Sinai SCORE site, including both project work and trainee pilot studies. While leveraging the expertise offered by an exceptional group of statistical epidemiologists, biostatisticians, bioinformaticians, and data scientists, the core activities are integrated with complementary resources across the SCORE site.


Type: Biostatistics & Informatics Core
Co-Leads: Susan Cheng, M.D., M.P.H., M.M.Sc., & Andre Rogatko, Ph.D.
Co-Investigator: Marcio Diniz, Ph.D.

The Biostatistical & Bioinformatics Core provides dedicated end-to-end support and resources for efficiently managing and analyzing eicosanoids data generated from diverse human, animal, and cell biospecimens in relation to microvascular aging traits across the Cedars-Sinai SCORE site, including both project work and trainee pilot studies. While leveraging the expertise offered by an exceptional group of statistical epidemiologists, biostatisticians, bioinformaticians, and data scientists, the core activities are integrated with complementary resources across the SCORE site.

Type: Eicosanoids Profiling Core
Lead: Mohit Jain, M.D., Ph.D.
Co-Investigator: Jeramie Watrous, Ph.D.

The Eicosanoids Profiling Core provides dedicated high-throughput mass spectrometry eicosanoid profiling services for the diverse human, animal, and cell biospecimens that will be generated from across the SCORE site’s studies. The core is specifically optimized to enable the application of robust and reproducible measure of up to 500 eicosanoids per sample across thousands of samples from any given project. Additionally, the core provides an accurate and unified framework for standardizing and integrating high-dimensional eicosanoids data across multiple projects. While leveraging the expertise offered by an exceptional group of analytical chemists, mass spectrometrists, structural biologists, and computational biologists, the core activities are integrated with complementary resources across the SCORE site.

SCORE Directors: Igho Ofotokun, M.D., and Lisa B. Haddad, M.D.
Grant: U54AG062334
Title: Emory Specialized Center of Research Excellence (SCORE) on Sex Differences

OVERVIEW: The Emory SCORE is focused on the influence of biological sex on microbial–host–pathogen interactions, using HIV as a model for probing the nature of these interactions. The working hypothesis is that HIV-induced inflammation co-acts with that induced by estrogen insufficiency to heighten the inflammatory state among women living with HIV, thereby worsening age-related comorbidities in this population. The long-term goal of the Emory SCORE is to develop a program to serve as a regional hub for studying the influence of biological sex on the outcomes of infectious diseases and for promoting the normalization of sex as a biological variable (SABV) in research.

Three cross-cutting research projects will explore the synergy between HIV-induced immune activation and chronic inflammation and that induced by estrogen insensitivity observed in women aging with HIV infection.

  • Research Project 1: Neuro–hypothalamic–pituitary–adrenal axis 
    MPIs: Gretchen Neigh, Ph.D., and Vasiliki Michopoulos, Ph.D.

    The goal of the project is to identify factors contributing to HIV-associated chronic inflammation in women. These studies are critical for providing the framework needed to design therapeutic strategies aimed at resolution of the chronic inflammation in women living with HIV.
  • Research Project 2: Musculoskeletal 
    MPIs: M. Neale Weitzmann, Ph.D., and Igho Ofotokun, M.D. 

    The project will test the hypothesis that enhanced fracture risk observed in women living with HIV is caused by the collision between HIV/antiretroviral therapy–induced inflammation and that induced by estrogen insufficiency as women living with HIV age.
  • Research Project 3: Cardiovascular 
    MPIs: Arshed Quyyumi, M.D., and Leslee J. Shaw, Ph.D.

    The goal of the project is to assess the combined immune effects of HIV and estrogen status described in Project 1 and Project 2 on cardiovascular health as assessed by endogenous reparative/regenerative capacity (circulating progenitor cells) and the development/progression of subclinical coronary (CT angiography) and carotid artery (MRI) atherosclerosis in women living with HIV compared with HIV-negative controls.

Co-Directors: Marcia Holstad, Ph.D., and Kelli Stidham Hall, Ph.D.

The role of the Career Enhancement Core (CEC) is to prepare the next generation of women’s health researchers to capitalize on Emory’s considerable strengths in prevention science, infectious disease research, clinical and translational research, basic immunology, and antiviral drug development within the context of the National Institutes of Health’s (NIH) recently outlined steps to promote sex considerations in the design and conduct of all research, including the basic sciences.

SCORE Director: Sabra L. Klein, Ph.D. 
Grant: U54AG062333
Title: Sex and Age Differences in Immunity to Influenza (SADII)

OVERVIEW: The Sex and Age Differences in Immunity to Influenza (SADII) SCORE is positioned to transform our understanding of the role of biological sex, gender, and aging on immune responses to influenza vaccination, which has global public health implications, affecting millions of people worldwide. The overarching hypothesis: Female-biased vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal and genetic differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens. The SADII SCORE brings together investigators focused on (1) seasonal influenza vaccination in an existing age- and sex-stratified human population, (2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations, and (3) the contributions of age, frailty, sex, and gender to vaccine outcomes using quantitative and qualitative statistical models. 


  • Research Project 1: Sex differences in longitudinal humoral immunity against influenza in the frail elderly

    This research project is led by Dr. Sean Leng, in collaboration with the Johns Hopkins University Older Americans Independence Center. The goal of this project is to provide a detailed analysis of sex and gender differences in humoral immunity and adverse reactions to seasonal influenza vaccines in combination with age and frailty in an existing longitudinal cohort of older individuals.
  • Research Project 2: Sex differences in immune responses to vaccine and circulating strains of influenza in health care workers

    This research project is led by Dr. Andrew Pekosz, in collaboration with the Johns Hopkins Center of Excellence in Influenza Research and Surveillance (JH-CEIRS). The study will characterize the number and transcriptional activity of B cells, as well as humoral immune responses and adverse reactions, following receipt of seasonal influenza vaccines. The study will be focused on men and women between the ages of 18 and 45, to provide an age- and sex-stratified cohort to assess sex differences in vaccine responses among adults.
  • Research Project 3: Genetic and hormonal mechanisms of sex differences in immune responses and influenza vaccine efficacy in young and aged mice

    This research project is led by Dr. Sabra Klein. The goal of the project is to uncover the genetic, hormonal, and age-associated changes in B cells that mediate sex and age differences in vaccine-induced immunity to influenza. This will be accomplished by a systematic evaluation of the effects sex hormones and genes encoded by sex chromosomes have on the antibody response to influenza vaccination.

Director: Wendy Bennett, M.D.

The SADII Career Enhancement Core (CEC) is led by Dr. Wendy Bennett, in collaboration with the Johns Hopkins Center for Women’s Health, Sex, and Gender Differences. Aims include: 

  • Providing collaboration, networking, dissemination, and mentoring opportunities
  • Providing pilot grant funding for early-stage investigators (i.e., investigators at the level of assistant professor or below), with emphasis on diversity of candidates, interested in incorporating sex differences into their clinical, translational, or basic science research in the broad area of immunology (e.g., asthma and allergy, autoimmunity, cancer, infectious diseases, inflammation, microbiome, and vaccines) 
  • Integrating educational opportunities focused on teaching skills and methods for incorporating sex as a biological variable and gender considerations when planning, analyzing, and reporting data, as well as research dissemination activities in regard to a broad range of existing training programs (e.g., KL2 and BIRCWH programs)
  • Evaluating the effectiveness of the SADII CEC in expanding learning opportunities, dissemination of sex and gender research, mentorship, and funded research

SCORE Directors: Jill M. Goldstein, Ph.D., & Stuart A. Tobet, Ph.D.
Grant: U54MH118919
Title: Sex Differences in Major Depression: Impact of Prenatal Stress- Immune and Autonomic Dysregulation

OVERVIEW: The scientific mission of the MGH/Harvard-CO SCORE is to identify stress-immune pathway abnormalities, beginning in fetal development, that have shared adverse consequences for sex differences in brain circuitry regulating mood, stress and risk for major depressive disorder (MDD) comorbid with autonomic, neurovascular dysfunction and cardiovascular disease risk in midlife. This program is facilitating transdisciplinary, translational collaborations among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central and peripheral autonomic and vascular function and develop a novel non-invasive neuromodulation therapeutic targeted to the neural-cardiac interface in a sex-selective manner. Further, the MGH/Harvard-CO SCORE aims to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD, autonomic dysregulation, and cardiovascular risk to the scientific and medical communities, policy makers, and the public.  


  • Research Project 1: Impact of Sex on Prenatal Stress-Immune Programming of Depression and Autonomic Dysregulation
    Lead: Jill M. Goldstein, Ph.D.

    The goal of the project is to test the hypothesis that immune pathway abnormalities, beginning in fetal development, are associated with sex-dependent impacts on the stress response circuitry in the brain, resulting in lifelong recurrent MDD, and dysregulation of hormonal and immune responses to stress, autonomic, and neurovascular dysfunction in midlife. This is possible given the unique >60-year follow-up of a prenatal cohort of offspring now turning about 57-62 years of age in whom the researchers conduct adult multi-modal imaging and deep clinical phenotyping, genetics/genomics research, and assays of blood-based biomarkers in prenatal development and midlife.
  • Research Project 2: Sex-Dependent Impact of Transcutaneous Vagal Nerve Stimulation on the Stress Response Circuitry and Autonomic Dysregulation in Major Depression
    Co-Leads: Vitaly Napadow, Ph.D., and Ronald G. Garcia, M.D., Ph.D. 

    This project will test the hypothesis that expiratory-gated transcutaneous vagus nerve stimulation (tVNS) can effectively modulate specific brainstem–cortical pathways of the stress response circuitry and attenuate cardiophysiologic and neurovascular dysfunction in recurrent MDD in a sex-dependent manner. Case subjects in project 1 will be assessed in project 2, as well.
  • Research Project 3: Sex Differences in Fetal Programming by Glucocorticoids: Adult Hypothalamus and Autonomic Nervous System
    Co-Leads: Stuart A. Tobet, Ph.D., and Taben Hale, Ph.D.

    The overall goal of this project is to identify the cellular and physiological pathways that are affected by overexposure to glucocorticoids (or maternal stress) and implicated in long-term, sex-selective alterations in anxiety- and depressive-like behaviors, neuroendocrine function, and autonomic (e.g., cardiovascular) responses to stress in the offspring. Results will identify brain regions or vasculature and their connectivity that are responsible for the sex-biased developmental alterations in behavioral, endocrine, and autonomic responses in adulthood. Causal mechanisms involving the renin-angiotensin system will be specifically tested. Further, the project will evaluate the use of a tVNS device (in parallel to project 2) to restore autonomic function and behavioral responses in adult rats that were exposed to stress in utero.


Co-Leads: Stuart A. Tobet, Ph.D., Joshua Roffman, M.D., Jordan W. Smoller, M.D., Sc.D., and Albert Hofman, M.D., Ph.D.

The Career Enhancement Core (CEC) will contribute to training the next generation of scientists and clinician-scientists as leaders in the fields of women’s health and sex differences in medicine. They will be empowered to contribute to understanding sex-dependent vulnerabilities to mood and anxiety disorders and associated cardiometabolic diseases. To enhance the careers of SCORE trainees, the CEC will specifically: 1) integrate levels of training and thought about etiologic mechanisms at basic and clinical levels for sex differences and for gender and health disparities at the policy level; 2) mentor trainees from a team perspective that exposes them to different levels of analysis from mentors with complementary expertise; 3) provide access to material and faculty resources that will enhance the success of the candidates; and 4) provide seed funding to supplement work with preclinical studies and ultimately translate to human studies.


Co-Leads: Vitaly Napadow, Ph.D., and Hang Lee, Ph.D.

The Resource Support Core (RSC) provides infrastructure and tools to enable a cohesive approach to the collection, analysis, storage, and sharing of data across the SCORE projects. The RSC also provides expert support in areas such as biostatistics, transcutaneous vagus nerve stimulation, and advanced autonomic and neuroimaging analyses. Establishing a unified approach will enhance the quality of all studies, allowing each project to inform the others in potentially significant ways and enabling valuable exploratory analyses through pooling data and translations between human and animal studies. 

MGH-SCORE website:

SCORE Directors: Kejal Kantarci M.D., and Michelle M. Mielke, Ph.D.
Grant: U54AG044170
Title: Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer’s Disease 

OVERVIEW: The Mayo Clinic Specialized Center of Research Excellence (SCORE) on Sex Differences promotes interdisciplinary approaches to advancing translational research on sex differences in health and disease. Research bridges results from basic science projects to clinical studies. The goal of the Mayo Clinic SCORE on Sex Differences is to understand how female-specific conditions associated with major hormonal shifts (e.g., menarche, pregnancy, and menopause) affect physical and cognitive decline in women as they age. During the first funding period (2012–2018), the Mayo Clinic SCORE’s research focused on how the sex-specific conditions of hypertensive pregnancy disorders and natural menopause, with and without menopausal hormone therapy, affected the risk of cardiovascular disease and cognitive decline. In this renewal application, the Mayo Clinic SCORE will extend these investigations to an extreme model of endocrine disruption: premenopausal bilateral salpingo-oophorectomy (BSO). About 1 in 8 women in the United States undergo BSO before reaching natural menopause. Although premenopausal BSO confers protection against ovarian cancer, it is associated with increased all-cause mortality, dementia, Alzheimer’s disease (AD) pathology, cardiovascular disease, skin aging, and sexual dysfunction. Given the large number of aging women with a history of premenopausal BSO, there is an urgent need to understand the long-term physical and cognitive outcomes to empower women considering prophylactic BSO to make more informed decisions. The central hypothesis of the Mayo Clinic’s SCORE renewal is that the abrupt endocrine disruption caused by premenopausal BSO will accelerate pathological aging processes that manifest as reductions in physical and cognitive function and in AD. This hypothesis will be tested through three interrelated translational projects, which are supported by three interdependent cores. 


  • Research Project 1: Effects of bilateral salpingo-oophorectomy on physical and cognitive aging
    PI: Michelle M. Mielke, Ph.D.
    Co-Investigators: Walter A. Rocca, M.D., Julie A. Fields, Ph.D., and Nathan K. LeBrasseur, Ph.D.

    The primary objective of Project 1 is to determine whether premenopausal bilateral salpingo-oophorectomy (BSO) is associated with accelerated aging as measured by a higher frailty score, a greater decline in physical and cognitive function, and higher plasma levels of senescence-associated secretory phenotype (SASP) proteins compared with referents. The SASP proteins are also used as the primary aging biomarker in Project 3.
  • Research Project 2: Effects of bilateral salpingo-oophorectomy on imaging biomarkers of Alzheimer’s disease and cerebrovascular diseases 
    PI: Kejal Kantarci, M.D.
    Co-Investigator: Kent R. Bailey, Ph.D.

    The primary objective of Project 2 is to assess the effects of premenopausal bilateral salpingo-oophorectomy (BSO) on neuroimaging measures of Alzheimer’s disease and cerebrovascular pathology and to determine whether APOE-ε4 modifies these effects. In addition, the relationship between the neuroimaging biomarkers and the cognitive outcomes measured in Project 1 will be determined.
  • Research Project 3: Effects of bilateral ovariectomy on the biology of physical and cognitive aging in mice
    PI: Nathan K. LeBrasseur, Ph.D.
    Co-Investigators: Marissa J. Schafer, Ph.D., and Sundeep Khosla, M.D.

    As a mechanistic complement to the human projects, Project 3 will use mice, with the primary objective of determining the effects of ovariectomy (OVX) on cellular senescence, senescence-associated secretory phenotype (SASP), and measures of physical and cognitive function that parallel those in Projects 1 and 2. In addition, the temporal sequence and tissue-specific effects of estrogen replacement therapy on cellular senescence will be determined.

Director: Virginia M. Miller, Ph.D.

The Career Enhancement Core (CEC) will provide career enrichment, leadership training, and funds to support ancillary studies of the main projects to stimulate new interest in sex differences and women’s health. The Mayo Clinic SCORE will serve as a vital hub for education and dissemination of innovative sex-based translational research methods, results, and best practices. The Mayo Clinic SCORE’s integrated approach for research, training, and education is consistent with the goals of the SCORE on Sex Differences program and ensures continuing research in areas of women’s health and sex differences by training the workforce of the future. 

Director: Ekta Kapoor, M.B.B.S.

The Resource Support Core – Clinical will provide centralized, coordinated support, management, and oversight for the human studies of the SCORE (Projects 1 and 2). Specific functions include recruiting, screening, consenting, and enrolling study participants; coordinating and completing clinical and neuroimaging visits; and maintaining and managing a shared database.

SCORE Directors: Aimee McRae-Clark, Pharm.D., and Kevin Gray, M.D. 
Grant: U54DA016511
Title: MUSC Specialized Center of Research Excellence on Sex Differences

OVERVIEW: The MUSC Specialized Center of Research Excellence (SCORE) on Sex Differences has been highly productive for 20 years. In addition to convening a multidisciplinary group of investigators to work closely together to explore sex and gender differences in substance use disorders and the relationship between stress and drug use, the MUSC SCORE has provided a fertile training ground for new investigators and has attracted senior investigators to apply their skills to sex- and gender-specific research. The specific aims of this SCORE are to support and enhance translational scientific collaborations among the investigators conducting primary and pilot research projects, catalyze further growth of interdisciplinary sex- and gender-based research on the MUSC campus, continue foundational research training for early-career investigators dedicated to sex- and gender-focused translational research, and promote strategic partnerships to enhance the translation and dissemination of SCORE findings and other relevant research to improve health outcomes. During the renewal period, we are continuing to reach across the MUSC campus, South Carolina, and the nation through cross-SCORE collaborations and other initiatives focused on dissemination of research findings to improve health outcomes. The science within our research group includes four tightly integrated research projects. To address critical public health needs, these research projects investigate sex differences in cannabis use disorders across the lifespan, focusing on populations with recent rapid increases in cannabis use and potential vulnerability to sex-disparate harms of cannabis (i.e., emerging adults, postpartum women, and older adults). 

The four well-integrated translational research projects will investigate sex differences in cannabis use disorders and directly inform addiction treatment development.

  • Research Project 1: Sex differences in the interface between cannabis use and stress among emerging adults
    MPIs: Kevin Gray, M.D. and Rachel Tomko, Ph.D. 

    The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults. Given the dynamics at play during this critical stage when cannabis use is most prevalent, developmentally informed research is needed to guide tailored clinical interventions. This study applies rigorous and innovative methods to elucidate sex differences in the nexus of cannabis use and stress among emerging adults with cannabis use disorder to guide the development of tailored treatments. 

  • Research Project 2: Impact of stress and craving on return to cannabis use in postpartum women
    MPIs: Connie Guille, M.D., MSCR and Kathleen Brady, M.D., Ph.D.
    Co-Investigators: Roger Newman, M.D.

    Although most women who use cannabis will reduce their cannabis use during pregnancy, almost all women will return to cannabis use postpartum. Longitudinal studies are needed to examine the relationships between stress, progesterone, and return to cannabis use in postpartum women. This study will help to inform the development of gender-specific, targeted interventions that prevent postpartum return to cannabis use and improve women’s health.

  • Research Project 3Sex differences in risk of cognitive decline in older cannabis users
    MPIs: Aimee McRae-Clark, Pharm.D. and Andreana Benitez, Ph.D. 

    Cannabis is the most frequently used illicit substance by older adults, and its use among persons ages 50+ is rising. Little is known about the potential harms of cannabis use in this population, such as the impact on cognitive decline and risk for Alzheimer’s disease and related dementias, and whether sex differences in stress and hormones influence these risks. This project will study cannabis-using older men and women to answer these questions to inform public health messaging on cannabis use and to identify potential clinical interventions for older adults.

  • Research Project 4: Preclinical component
    PI: Rachel Penrod-Martin, Ph.D.
    Co-I: Onder Albayram, Ph.D.

    Legalization of cannabis products for recreational use has increased rates of cannabis use and cannabis use disorder across multiple vulnerable groups, including adolescents/young adults, pregnant women, and older adults. Despite legalization, the neurobiological impacts of acute and chronic cannabis use, and how they are affected by sex and age, largely remain uninvestigated. This component, and the associated Clinical Projects 1-3, will investigate how the active components of cannabis impact learning and memory, relapse behavior, and brain function at the molecular level in vulnerable populations.


Director: Aimee McRae-Clark, Pharm.D.

The Leadership Administrative Core (LAC) is the hub of the MUSC SCORE, serving as the central coordinating point for all SCORE activities. It influences each of the research projects and Center cores and brings together the various components to form a cohesive, functioning unit. The LAC also oversees SCORE outreach, collaboration, and evaluation efforts.


Director: Kathleen T. Brady, M.D., Ph.D.

The SCORE Career Enhancement Core (CEC) provides a formal, intensive program of mentored clinical and translational research training and career development activities to promote junior scholars in the area of sex- and gender-based clinical and translational research focused on the impact of stress on human health. Training scientists with an understanding of the role of sex and gender in the etiology and pathophysiology of specific disease states will enable optimization of the personalized approaches to diagnosis and treatment that are essential to improving the health of both men and women.


MPIs: Nathaniel Baker, M.S. and Brian Neelon, Ph.D.
Co-I: Rachel Tomko, Ph.D.

The Biostatistical Resource Core provides centralized support to the entire MUSC SCORE team of investigators and strives to promote synergy in terms of study design and analyses across projects and other shared resources. It also contributes to the career enhancement mission of the MUSC SCORE.

SCORE Director: Karen Reue , Ph.D.
Grant: U54DK120342
Title: Sex Differences in the Metabolic Syndrome

OVERVIEW: The objective of the UCLA SCORE is to elucidate sex differences in risk factors and treatments for metabolic syndrome (MetSyn) components, such as obesity, insulin resistance/diabetes, dyslipidemia, and fatty liver. Differences between men and women in susceptibility to cardiometabolic disease are well known, but the underlying genetic and physiological mechanisms remain poorly defined. Our goal is to identify factors that determine sex-specific MetSyn risk, which may lead to better diagnosis and treatment for both sexes. A unique feature of the UCLA SCORE is the investigation of sex differences in MetSyn from multiple perspectives, including the impact of having an XX versus an XY sex chromosome complement, interactions between sex and genetic variation, and estrogen effects. This triad converges in the study of how each of these components influences metabolism at the genetic and epigenetic levels. 

The UCLA SCORE consists of three cross-cutting research projects and three cores and will use preclinical models and human tissue samples. 

  • Research Project 1: Sex chromosome effects on metabolic syndrome risk and treatment
    Lead: Karen Reue, Ph.D.

    This project will build on the finding that the presence of XX compared with XY chromosomes increases susceptibility to obesity and related traits. Much of the XX effect is attributable to a specific X chromosome gene that escapes X chromosome inactivation and acts at higher levels in female (XX), compared with male (XY), cells. The effects of this gene dosage on the epigenetic regulation of gene expression, energy balance, and adipose tissue remodeling during obesity will be defined. Also, the XX chromosome effect on increased female risk for diabetes secondary to statin drug therapy will be elucidated, and a dietary co-therapy that may alleviate this sex-biased adverse drug response will be tested.
  • Research Project 2: Gene-by-sex interactions in mitochondrial functions and metabolic syndrome traits
    Lead: Jake Lusis, Ph.D.

    This project seeks to understand the roles of both genetics and sex in metabolic syndrome (MetSyn) traits. Results of a systems genetics approach have implicated sex- and tissue-specific action of specific genes on MetSyn traits. The project will elucidate sex effects on mitochondrial functions in insulin resistance, as well as sex-specific effects of genes that have been implicated in insulin resistance and hepatic steatosis. The gene-by-sex interactions discovered in mice will be tested in tissues from human cohorts.
  • Research Project 3: The impact of estrogen receptor (ER) in metabolic health
    Lead: Andrea Hevener, Ph.D.

    This project will test the hypothesis that muscle estrogen receptor (ER) protects against metabolic dysfunction in mice and women, identify ER regulatory sites across the genome in females and males, and elucidate the effect of ER on the regulation of mitochondrial function. Results may provide proof-of-concept evidence that skeletal muscle ER is an effective therapeutic target to combat metabolic dysfunction and type 2 diabetes.

Lead: Arthur P. Arnold, Ph.D.

The Career Enhancement Core (CEC) proposes an integrated set of educational and research support activities to foster development of research at UCLA in women’s health and sex as a biological variable (SABV) in disease, especially related to sex differences in metabolic syndrome. The aim is to spread the word about when and how sex has an important effect on physiology and disease and to teach best practices for investigating sex-biasing factors (e.g., gonadal hormones and sex chromosomes) that affect disease. The CEC intends to seed and incubate fledgling research projects and build an interactive community of investigators at UCLA and nationally that consider women’s health and sex differences in their research. Key activities include workshops on clinical and experimental approaches to study SABV, a Pilot and Feasibility grant program to enhance the ability of investigators to perform SABV-relevant research, and lectures by invited speakers who study women’s health and SABV, in coordination with UCLA undergraduate programs and courses. Involvement of underrepresented minority students in exciting research on women’s health and SABV will be emphasized.

Lead: Matteo Pellegrini, Ph.D.

The Genomic Technologies Core provides next-generation sequencing and bioinformatic analysis of transcriptomic RNA sequencing, ATAC-seq, and ChIP-seq data to enhance understanding of molecular mechanisms underlying sex differences in metabolic syndrome. 

Additional information is available at

SCORE Directors: Emeran Mayer, M.D., & Lin Chang, M.D.
Grant: U54DK123755
Title: Sex Related Differences in Brain Gut Microbiome Interactions in Irritable Bowel Syndrome

OVERVIEW: This SCORE proposal aims to gain a better understanding of the role of the gut microbiome and female sex hormones in the modulation of brain–gut microbiome interactions in two of the most common disorders of the gastrointestinal tract, irritable bowel syndrome (IBS) and chronic functional constipation. These disorders are more prevalent in women than men, and their pathophysiology is not completely understood. While there are some treatments available to treat symptoms, the majority of patients report lack of satisfaction with current treatments. The proposed studies will compare brain–gut microbiome interactions in (1) women with IBS and healthy women during low estrogen states (perimenstrual, postmenopausal), (2) women and men with IBS and healthy women and men, and (3) premenopausal women with normal and slow transit constipation and healthy women. In addition, the proposed studies will study gut microbial and brain mechanisms underlying the effectiveness of cognitive behavioral therapy in women and men with IBS. Results obtained from the proposed studies are likely to provide significant insights on the pathophysiology and treatment of these disorders.


The three well-integrated translational research projects will investigate sex differences in brain–gut microbiome interaction in IBS.

  • Research Project 1: The primary objective of this project is to examine the role of brain–gut microbiome interactions in mediating IBS and constipation symptoms during menses and menopause
    Co-Leads: Lin Chang, M.D., & Arpana Gupta, Ph.D.

    This grant will provide new insights into the pathogenesis of IBS and normal transit constipation (symptoms of constipation in the absence of changes in transit or defecation), which are highly prevalent gastrointestinal disorders that occur more commonly in women and are associated with a significant health care and economic burden, decreased quality of life, and lack of satisfactory treatment. The proposed studies expand novel insights gained from our preliminary data into the role of sex as a biological variable in altered brain–gut microbiome interactions and clinical symptoms of IBS and normal transit constipation. These insights have the potential to identify endophenotypes within women with IBS and chronic constipation that can lead to the development of novel treatment approaches.
  • Research Project 2: Sex-related differences in structure, function, and connectivity of central arousal and salience networks involving brain stem nuclei are involved in IBS symptom generation
    Co-Leads: Jennifer Labus, Ph.D., & Benjamin Ellingson, Ph.D. 

    Even though IBS is now considered a brain–gut disorder, the underlying biological mechanisms and the role of sex-related differences are not completely understood. By studying men and women with IBS and healthy women and men, we propose to study sex-related differences in the structure and function of brain networks that are relevant for IBS and to characterize the modulation of these networks by gut microbial metabolites and estrogen. The results from the proposed studies are likely to identify novel targets for IBS drug development, with particular relevance for female patients.
  • Research Project 3: The primary object of this project is to examine sex-related differences in the effect of cognitive behavioral therapy on emotional arousal and salience circuits and the role of the gut microbiome.
    Co-Leads: Emeran Mayer, M.D., & Bruce Naliboff, Ph.D.

    Cognitive behavioral therapy is an effective treatment for IBS, but the biological mechanisms underlying its effectiveness and the role of biological sex are not known. The proposed study aims to examine the role of the gut microbiome and its interactions with brain and brain stem regions, as well as clinical and behavioral variables, and determine the role of biological sex in these interactions and in clinical outcomes. The results from this study have the potential to identify subgroups of patients highly responsive to therapy, as well as underlying biological mediators.


Co-Leads: Emeran Mayer, M.D., & Lin Chang, M.D.

The Career Enhancement Core (CEC) will be responsible for implementing innovative programs to enhance collaborations, training, education, recruitment of new investigators, and community outreach. The CEC will oversee the pilot and feasibility programs to provide seed grant funding, the recruitment and mentoring of young investigators, organization of educational conferences, and community outreach. Involvement of underrepresented minority students and trainees in research on women’s health and sex as a biological variable will be encouraged. The CEC will closely interact with UCLA’s Sex Differences in Metabolism SCORE.


Co-Leads: Arpana Gupta, Ph.D., Jennifer Labus, Ph.D., & Jonathan Jacobs, M.D., Ph.D.
Co-Investigators: Lisa Kilpatrick, Ph.D., & Swapna Joshi, Ph.D.

The Data Processing and Analysis Core will provide the advanced microbiome, metabolomics, and neuroimaging tools and technologies necessary to analyze the interactions of neurobiological and molecular mechanisms underlying the brain–gut microbiome axis, sex differences in this system, the influence of hormones on this system, and how cognitive behavioral therapy alters this system. Elucidation of brain–gut microbiome pathways cannot be achieved by analysis of microbiome and neuroimaging data sets in isolation. Integration of these distinctive omics data sets to find biologically meaningful relationships represents a frontier in bioinformatics that will be critical to identifying novel diagnostic and therapeutic targets for IBS.

SCORE Director: Wendy M. Kohrt , Ph.D.
Grant: U54AG062319
Title: Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function

OVERVIEW: The University of Colorado Specialized Center of Research Excellence on Sex Differences (CO-SCORE) is thematically focused on bioenergetic and metabolic consequences of the loss of gonadal function. The overarching scientific objective of the CO-SCORE is to advance knowledge of the impact of gonadal aging on the regulation of bioenergetics, abdominal adiposity, and metabolism by conducting mechanistically driven research across the basic-to-clinical translational spectrum. The scientific premise is that gonadal failure mediates biological changes that increase risk for chronic disease. The most well-studied example of this is the accelerated decline in bone mineral density at menopause and the associated osteoporosis risk. However, the extent to which gonadal failure increases risk for chronic diseases other than osteoporosis is poorly understood. The three research projects (basic, preclinical, and clinical) will advance cutting-edge, paradigm-challenging translational research on novel mechanisms postulated to contribute to the increased abdominal adiposity and associated metabolic dysfunction that occur in the estrogen-deficient state.


  • Research Project 1: Bioenergetic and metabolic consequences of the loss of gonadal function in women
    PI: Wendy M. Kohrt, Ph.D.
    Co-Investigators: Daniel H. Bessesen, M.D., Edward L. Melanson, Ph.D., Kerrie L. Moreau, Ph.D., and Margaret E. Wierman, M.D.

    Project 1 is based on the overarching hypothesis that the loss of gonadal function increases risk for chronic disease. This is particularly relevant to women’s health because gonadal failure is inevitable in women in midlife but rare in men until much later in life. Aim 1 in the current award period is to determine whether adipose tissue and systemic glucocorticoid metabolism are regulated by estradiol (E2) in women. Because a goal of the CO-SCORE is to advance paradigm-challenging research on sex differences, Aim 2 will investigate follicle-stimulating hormone (FSH) as a mediator of energy homeostasis and cardiometabolic function. Projects 1, 2 (preclinical), and 3 (basic) will all address gaps in knowledge on whether the effects of E2 deficiency to increase abdominal adiposity are mediated by altered glucocorticoid metabolism and/or increased FSH. Adipose tissue samples from women in Project 1 and from animals in Projects 2 and 3 will be interrogated using similar approaches to accelerate the translational relevance of these areas of research. Finally, because blood and tissue samples from experiments in which we control E2 status are of great value across many disciplines, we will bank specimens from women in Project 1 so they can be used to support external collaborations with SCORE (and other) investigators across the country.
  • Research Project 2: Mediators of metabolic decline with the loss of gonadal function
    PI: Paul S. MacLean, Ph.D.
    Co-Investigators: Matthew R. Jackman, Ph.D., Michael C. Rudolph, Ph.D., and Elizabeth A. Wellberg, Ph.D.

    The overarching scientific objective of the CO-SCORE is to advance our understanding of how gonadal aging affects bioenergetics, abdominal adiposity, metabolism, and disease risk by conducting mechanistically driven research across the basic-to-clinical translational spectrum. CO-SCORE Project 2 will leverage preclinical models and interventions to provide a bidirectional, basic-to-clinical translational bridge between the clinically relevant studies of Project 1 and the basic discovery studies in Project 3. The long-term objective of Project 2 is to work collaboratively with CO-SCORE investigators to develop better strategies for treating and preventing the pathological consequences of gonadal aging, which disproportionately afflict women.
  • Research Project 3: Sex hormones differentially regulate production of a distinct adipocyte population
    PI: Dwight J. Klemm, Ph.D.
    Co-Investigators: Kathleen M. Gavin, Ph.D., and T. Rajendra Kumar, Ph.D.

    The menopausal transition, an unavoidable aging-related phenomenon in women, is accompanied by increased abdominal adiposity and the concomitant incidence of adipose-related comorbidities. We have generated evidence that the cellular composition of adipose tissue (AT) defines the phenotype of each individual depot, determining its overall influence on metabolic health. The premise is that the loss of gonadal hormones alters the cellularity of AT, leading to changes in body fat distribution and worsening metabolic health. We previously discovered a novel lineage of adipocytes in the major white adipose depots of mice and humans generated from bone marrow–derived cells of the hematopoietic lineage rather than conventional mesenchymal precursors. In mice, bone marrow–derived adipocytes (BMDAs) were detected in greater numbers in abdominal fat depots and displayed increased inflammatory cytokine but decreased leptin and mitochondrial lipid oxidation gene expression, suggesting a critical role in influencing metabolic health. Furthermore, ovariectomy (OVX) significantly increased BMDA production, which was attenuated by estradiol (E2) replacement. In addition to declines in E2, menopause and OVX are also characterized by rising follicle-stimulating hormone (FSH) levels. Recent research raises the possibility that the consequences of menopause traditionally attributed to the specific loss of ovarian E≠ are instead caused by the previously unappreciated rise in FSH. Here we test the central hypothesis that E2 and FSH differentially regulate the production of BMDAs, altering the cellular composition of AT and resulting in significant changes in metabolic and inflammatory phenotype. Successful completion of these studies will define the roles of E2 and FSH in controlling the production of BMDAs, which may contribute to postmenopausal metabolic pathology. These data have the tremendous potential to highlight BMDA production as a new therapeutic target and provide novel strategies for the prevention of menopausal and aging-related chronic disease risk.

Director: Judith G. Regensteiner, Ph.D.

The objectives of the CO-SCORE CEC are to develop and support a cadre of accomplished junior researchers in the thematic focus of the CO-SCORE, “Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function,” and to provide a curriculum that meets the career enhancement needs of postdoctoral research fellows and junior faculty scientists focused on translational science in the study of women’s health and sex differences. The SCORE scholars will receive salary support to protect time for research and funds for research project support. In addition, meritorious pilot projects, selected through peer review, will be awarded to three promising scientists each year. SCORE scholars and pilot awardees will participate in an innovative career enhancement program, including team mentoring, hands-on research experience, and curricular training to cultivate academic skills and career development skills. Trainees will also participate in a summer course featuring relevant topics in endocrinology and receive training in methods and strategies for studying sex as a biological variable (SABV), which is being developed by the SCORE faculty. SCORE scholars and pilot awardees will undergo training with the trainees in the Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12, the Colorado Clinical and Translational Sciences Institute (CCTSI) KL2 program, and the Center for Women’s Health Research (CWHR) at the University of Colorado Anschutz Medical Campus. The mentoring, research experience, and curricular training provided by this program will provide pivotal support for the SCORE scholars and pilot awardees as they develop careers in women’s health and sex differences research. Expanding the workforce in this area is critical to the field’s becoming fully realized. Success in this endeavor means that health and disease in women and men will be optimally studied so that medical research benefits everyone to the highest level possible.

SCORE Director: Sherry McKee, Ph.D.
Grant: U54AA027989
Title: Yale-SCORE on Sex Differences in Alcohol Use Disorder

OVERVIEW: The Yale-SCORE on Sex Differences in Alcohol Use Disorder (AUD) brings together a team of leading basic and clinical science experts to pursue an interdisciplinary, translational, cross-species program of research aimed at identifying novel therapeutics to address the recent surge in rates of AUD in women. Over the past 10 years, rates of AUD in women have increased by 84%, translating to 10.5 million women across the United States. Alcohol use is the third-leading cause of preventable morbidity and mortality in the United States, and women drinkers experience exacerbated health risks associated with alcohol consumption when compared with men. Food and Drug Administration–approved medications for AUD were primarily developed with samples of men, and none targets factors that differentially maintain drinking in women. A considerable body of data identifies that women are more likely to drink to regulate negative affect and stress, whereas men are more likely to drink for alcohol-related positive reinforcement. Our primary aim is to use a neurobiologically informed approach to expedite the development of sex-appropriate therapeutics targeting stress and negative affect, which differentially maintain drinking in women. 


  • Research Project 1:
    Lead: Sherry McKee, Ph.D.

    The primary aim of Project 1 is to examine sex differences in guanfacine’s effect on counteracting stress- and stimulation-based drinking behavior in the laboratory and improving clinical outcomes during a subsequent treatment phase.
  • Research Project 2:
    Lead: Kelly Cosgrove, Ph.D.

    The primary aim of Project 2 is to examine whether chronic alcohol consumption is associated with reductions in microglia and synaptic density and whether the impairment varies by sex. By sharing subjects with Project 1, we will examine sex differences in neurochemical markers of neurodegeneration in the living brains of patients with AUD and their relationship to critical clinical outcomes.
  • Research Project 3:
    Co-Leads: Marina Picciotto, Ph.D., & Yann Mineur, Ph.D.

    The primary aim of Project 3 is to identify and translate sex differences in the neurobiological mechanisms studied across Projects 1 and 2. Project 3 will examine the effects of stress and pharmacological targets on neuronal activity in the amygdala, neuroinflammation, and metabolism.


Lead: Ismene Petrakis, M.D.

This core will provide qualified junior faculty members with salary support and translational team mentorship to enhance their research career development focused on sex as a biological variable (SABV) and alcohol use. Core activities include translational team mentorship, a pilot program, a curriculum dedicated to education on SABV and sex differences in alcohol use, professional development experiences, and training in leadership skills.


Co-Leads: Ralitza Gueorguieva, Ph.D., & Ismene Petrakis, M.D.

This core will provide research-related resources to the animal and human projects, including management of regulatory issues, comprehensive recruitment, a core battery, data management, and project design and statistical methods that incorporate state-of-the-art SABV approaches.