Bench to Bedside: Integrating Sex and Gender to Improve Human Health was developed in partnership with the Food and Drug Administration (FDA) Office of Women’s Health (OWH) to explore sex- and gender-related differences in key disease areas. Click here for information on course authors, reviewers, and leadership.
Module 1: Immunology
Through a focus on autoimmune diseases, asthma, and vaccine responses (especially the influenza vaccine), this module gives learners the knowledge to:
- Describe key epidemiological data associated with sex differences in the prevalence and outcomes of immunological disease, as well as vaccine efficacy and acceptance.
- Identify the tools available to study sex differences and their outcome measures in preclinical models.
- Describe clinical studies related to sex effects on therapeutic treatments of immunological disease, as well as the efficacy of vaccines.
- Recognize knowledge gaps and biases associated with our understanding of sex differences in immune responses.
Module 2: Cardiovascular Disease [coming soon]
This module explores sex and gender differences in cardiovascular disease via three major topics: heart failure with preserved ejection fraction (HFpEF), coronary microvascular dysfunction (CMD), and spontaneous coronary artery dissection (SCAD). After completing the module, learners will be able to:
- Identify gaps in research methodologies and public misconceptions associated with sex differences in cardiovascular disease.
- Identify sex differences in the presentation, risk factors, and pathophysiology of representative cardiovascular diseases.
- Describe how sex differences in risk factors and pathophysiology affect cardiovascular patient outcomes and disease management.
- Describe steps required to improve diagnosis and treatment of cardiovascular disease in women and men.
Module 3: Pulmonary Disease [coming soon]
The pulmonary disease module focuses on sex and gender differences in pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and pulmonary arterial hypertension (PAH). After completing the module, learners will be able to:
- Identify sex differences in the presentation, risk factors, and pathophysiology of pulmonary diseases.
- Describe how sex differences in pulmonary risk factors and pathophysiology affect patient outcomes and disease management.
- Identify opportunities to address gaps in knowledge via future research efforts.
- Describe how insights from pulmonary research can inform research design in other fields of study.