In coordination with the White House Initiative on Women’s Health Research, ORWH and several NIH institutes and centers issued a Notice of Special Interest (NOSI) to highlight interest in receiving research applications focused on diseases and health conditions that predominantly affect women (e.g., autoimmune diseases, depressive disorders, Alzheimer’s disease and Alzheimer’s disease-related dementias, gender-based violence), present and progress differently in women (e.g., cardiovascular disease, HIV, reproductive aging and its implications), or are female specific (e.g., uterine fibroids, endometriosis, menopause).

Applications should have a central focus on the health of women, as demonstrated through specific aims that either explicitly address a particular condition in women or focus on one of the following high-priority topics:

• Projects that investigate the influence of sex-linked biology, gender-related factors, or their intersections on health  
• Projects that investigate how physical, mental, and psychological health outcomes interact with structural factors to either mitigate or exacerbate health disparities, and aim to create behavioral interventions to address these issues
• Projects that advance the translation of research advancements and evidence in women’s health into practical benefits for patients and providers
• Projects to inform and develop multi-sector partnerships to advance innovation in women’s health research
• Research to increase public awareness of the need for greater investment in and attention to women’s health research, as well as women’s health outcomes across the lifespan
• Projects that advance research to reduce health disparities and inequities affecting women’s health, including those related to race, ethnicity, age, socioeconomic status, disability, and exposure to environmental factors and contaminants that can directly affect health
• Dissemination and implementation research to increase uptake of evidence-based interventions that advance women’s health
• Projects addressing topics identified in the Women’s Health Innovation Opportunity Map

In each of these potential areas of focus, intersectional and/or multidimensional approaches to gender-related social and structural variables—including race, ethnicity, socioeconomic status, and state and federal policies—are strongly encouraged.

The NOSI expires November 5, 2027. Check the individual Notice of Funding Opportunities for applicable receipt dates here.