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Office of Research on Women’s Health (ORWH)

Studying Sex to Strengthen Science

NIH is committed to improving health by supporting the rigorous science that drives medical advances.  Sex and gender influence health and disease, and considering these factors in research informs the development of prevention strategies and treatment interventions for both men and women.  Accordingly, NIH is calling on scientists to, when appropriate, take sex into account as they develop their research questions, design experiments, analyze data, and report results.

Read the NIH Director’s Statement

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Questions and Answers

NIH leaders discuss the ways NIH is addressing the influence of sex as a biological variable in NIH-funded research.

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Research Resources

NIH’s Office of Research on Women’s Health (ORWH) is committed to providing information and tools to the scientific community to help incorporate consideration of the biologic variable of sex in preclinical research design, analysis, and reporting.

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Research Spotlights

Learn what our researchers are discovering about the differences between the sexes in drug addiction, sleep and musculoskeletal lifespans.

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More Sex in Science News

NIH leaders discuss the ways NIH is addressing the influence of sex as a biological variable in NIH-funded research.

Additional GUIDANCE

Methods and Techniques for Integrating the Biological Variable Sex into Preclinical Research

Consideration of Sex as a Biological Variable in Biomedical Research: Analysis of Public Comments (PDF - 800 KB), Request for Information (RFI) Report

NIH Guide Notice: Consideration of Sex as a Biological Variable in NIH-funded Research, NOT-OD-15-102 View Additional Guidance(PDF - 74 KB)

NIH Strategic Plan for Women’s Health Research

Infographic: How Sex and Gender Influence Health and Disease
This page last reviewed on January 7, 2016