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SCOR Research News

Recent SCOR Publications


  • Flanagan JC, Baker NL, McRae-Clark AL, Brady KT, Moran-Santa Maria MM. Effects of adverse childhood experiences on the association between intranasal oxytocin and social stress reactivity among individuals with cocaine dependence. Psychiatry Res. 2015 Sep 30;229(1-2):94-100. PubMed PMID: 26231584; PubMed Central PMCID: PMC4546857.
  • Brady KT, McCauley JL, Back SE. Prescription Opioid Misuse, Abuse, and Treatment in the United States: An Update. Am J Psychiatry. 2016 Jan;173(1):18-26. PubMed PMID: 26337039; PubMed Central PMCID: PMC4782928.
  • Leong KC, Zhou L, Ghee SM, See RE, Reichel CM. Oxytocin decreases cocaine taking, cocaine seeking, and locomotor activity in female rats. Exp Clin Psychopharmacol. 2016 Feb;24(1):55-64. PubMed PMID: 26523890; PubMed Central PMCID: PMC4821810.
  • Moran-Santa Maria MM, Baker NL, McRae-Clark AL, Prisciandaro JJ, Brady KT. Effects of yohimbine and drug cues on impulsivity and attention in cocaine-dependent men and women and sex-matched controls. Drug Alcohol Depend. 2016 May 1;162:56-63. PubMed PMID: 26961964; PubMed Central PMCID: PMC4833507.
  • Gray KM, McClure EA, Baker NL, Hartwell KJ, Carpenter MJ, et al. An exploratory short-term double-blind randomized trial of varenicline versus nicotine patch for smoking cessation in women. Addiction. 2015 Jun;110(6):1027-34. PubMed PMID: 25727442; NIHMSID: NIHMS668188; PubMed Central PMCID: PMC4430389.
  • Saladin ME, Wray JM, Carpenter MJ, McClure EA, LaRowe SD, et al. Menstrual cycle phase effects in the gender dimorphic stress cue reactivity of smokers. Nicotine Tob Res. 2015 May;17(5):607-11. PubMed PMID: 25324432; PubMed Central PMCID: PMC4402356.
  • Zhou L, Ghee SM, See RE, Reichel CM. Oxytocin differentially affects sucrose taking and seeking in male and female rats. Behav Brain Res. 2015 Apr 15;283:184-90. PubMed PMID: 25647756; NIHMSID: NIHMS662841; PubMed Central PMCID: PMC4387851.
  • Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, et al. Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation. Nicotine Tob Res. 2015 Apr;17(4):407-21. PubMed PMID: 25762750; PubMed Central PMCID: PMC4429881.
  • Saladin ME, McClure EA, Baker NL, Carpenter MJ, Ramakrishnan V, et al. Increasing progesterone levels are associated with smoking abstinence among free-cycling women smokers who receive brief pharmacotherapy. Nicotine Tob Res. 2015 Apr;17(4):398-406. PubMed PMID: 25762749; PubMed Central PMCID: PMC4432400.
  • Wray JM, Gray KM, McClure EA, Carpenter MJ, Tiffany ST, et al. Gender differences in responses to cues presented in the natural environment of cigarette smokers. Nicotine Tob Res. 2015 Apr;17(4):438-42. PubMed PMID: 25762753; PubMed Central PMCID: PMC4432398.
  • Smith PH, Kasza KA, Hyland A, Fong GT, Borland R, et al. Gender differences in medication use and cigarette smoking cessation: results from the International Tobacco Control Four Country Survey. Nicotine Tob Res. 2015 Apr;17(4):463-72. PubMed PMID: 25762757; PubMed Central PMCID: PMC4402353.


  • Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM, Picciotto MR. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety and depression-like behavior. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3573-8. PubMed PMID: 23401542; PubMed Central PMCID: PMC3587265.
  • Malki K, Mineur YS, Tosto MG, Campbell J, Karia P, Jumabhoy I, Sluyter F, Crusio WE, Schalkwyk LC. Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains. BMC Genomics. 2015 Apr 3;16:262. PubMed PMID: 25879669; PubMed Central PMCID: PMC4412144.
  • Mazure CM, Jones DP. Twenty years and still counting: including women as participants and studying sex and gender in biomedical research. BMC Womens Health. 2015 Oct 26;15:94. PubMed PMID: 26503700; PubMed Central PMCID: PMC4624369.
  • Mazure CM. Our evolving science: studying the influence of sex in preclinical research. Biol Sex Differ. 2016;7:15. PubMed PMID: 26918114; PubMed Central PMCID: PMC4766639.
  • Cooper J, Borland R, McKee SA, Yong HH, Dugué PA. Depression motivates quit attempts but predicts relapse: differential findings for gender from the International Tobacco Control Study. Addiction. 2016 Feb 17. doi: 10.1111/add.13290. [Epub ahead of print] PubMed PMID: 26888199.
  • Mazure CM, Swendsen J. Alzheimer's Disease and other dementias: Examining sex differences. The Lancet Neurology, in press.
  • Kim, S., Kim, S., Seward, G., Fortuna, L., & McKee, S.A. (2013). Korean American women's experiences with smoking and factors associated with their quit intentions. ISRN Addiction. 2013. doi:10.1155/2013/79570765515 [Epub ahead of print]
  • Oberleitner LM, Smith PH, Weinberger AH, Mazure CM, McKee SA. Impact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men. Child Maltreat. 2015 Nov;20(4):301-8. doi: 10.1177/1077559515591270.Epub 2015 Jun 30. PubMed PMID: 26130105.
  • Verplaetse TL, Smith, PH, Pittman BP, Mazure CM, McKee SA (in press) Associations of gender, smoking, and stress with transitions in major depression diagnoses. Yale Journal of Biology and Medicine.
  • Verplaetse TL, McKee SA (in press) Nicotine use and alcohol self-administration:review of human laboratory findings. American Journal of Drug and Alcohol Abuse.
  • Verplaetse TL, McKee SA (in press) Targeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings Current Addiction Reports.


  • Hannan TJ, Mysorekar IU, Hung CS, Isaacson-Schmid ML, Hultgren SJ. Early severe inflammatory responses to uropathogenic E coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog. 2010 Aug 12;6(8):e1001042. PubMed PMID: 20811584; PubMed Central PMCID: PMC2930321.
  • Tenke P, Köves B, Nagy K, Hultgren SJ, Mendling W, Wullt B, Grabe M, Wagenlehner FM, Cek M, Pickard R, Botto H, Naber KG, Bjerklund Johansen TE. Update on biofilm infections in the urinary tract. World J Urol. 2012 Feb;30(1):51-7. PubMed PMID: 21590469; PubMed Central PMCID: PMC4629855.
  • Hibbing ME, Conover MS, Hultgren SJ. The unexplored relationship between urinary tract infections and the autonomic nervous system. Auton Neurosci. 2015 Jun 6;PubMed PMID: 26108548; PubMed Central PMCID: PMC4670803.
  • Conover MS, Flores-Mireles AL, Hibbing ME, Dodson K, Hultgren SJ. Establishment and Characterization of UTI and CAUTI in a Mouse Model. J Vis Exp. 2015 Jun 23;PubMed PMID: 26132341; PubMed Central PMCID: PMC4544389.
  • Wagers PO, Tiemann KM, Shelton KL, Kofron WG, Panzner MJ, Wooley KL, Youngs WJ, Hunstad DA. Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model. Antimicrob Agents Chemother. 2015 Sep;59(9):5494-502. PubMed PMID: 26124168; PubMed Central PMCID: PMC4538537.
  • Olson PD, Hruska KA, Hunstad DA. Androgens Enhance Male Urinary Tract Infection Severity in a New Model. J Am Soc Nephrol. 2015 Oct 8;PubMed PMID: 26449605.
  • Hannan TJ, Hunstad DA. A Murine Model for Escherichia coli Urinary Tract Infection. Methods Mol Biol. 2016;1333:159-75. PubMed PMID: 26468108; PubMed Central PMCID: PMC4624421.
  • Olson PD, Hunstad DA. Subversion of Host Innate Immunity by Uropathogenic Escherichia coli. Pathogens. 2016 Jan 4;5(1)PubMed PMID: 26742078; PubMed Central PMCID: PMC4810123.
  • Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL 4th, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A. Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures. J Urol. 2016 Jan 28;PubMed PMID: 26827873; NIHMSID: 755597.
  • O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ. Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiol Spectr. 2016 Feb;4(1)PubMed PMID: 26999391; NIHMSID: 733054.
  • Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA. Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis. 2016 Feb 15;213(4):649-58. PubMed PMID: 26347570; PubMed Central PMCID: PMC4721909.
  • Lim YH, Tiemann KM, Hunstad DA, Elsabahy M, Wooley KL. Polymeric nanoparticles in development for treatment of pulmonary infectious diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Mar 25;PubMed PMID: 27016134; NIHMSID: 764904.
  • Kline KA, Lewis AL. Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract. Microbiol Spectr. 2016 Apr;4(2)PubMed PMID: 27227294; NIHMSID: 731282.
  • Loughman JA, Yarbrough ML, Tiemann KM, Hunstad DA. Local Generation of Kynurenines Mediates Inhibition of Neutrophil Chemotaxis by Uropathogenic Escherichia coli. Infect Immun. 2016 Apr;84(4):1176-83. PubMed PMID: 26857571; PubMed Central PMCID: PMC4807489.
  • Conover MS, Hadjifrangiskou M, Palermo JJ, Hibbing ME, Dodson KW, Hultgren SJ. Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis. MBio. 2016 Apr 12;7(2)PubMed PMID: 27073089.


  • Brown CM, Garovic VD. Drug treatment of hypertension in pregnancy. Drugs. 2014 Mar;74(3):283-96. PubMed PMID: 24554373; PubMed Central PMCID: PMC4558097.
  • Faubion SS, Kuhle CL, Shuster LT, Rocca WA. Long-term health consequences of premature or early menopause and considerations for management. Climacteric. 2015;18(4):483-91. PubMed PMID: 25845383; PubMed Central PMCID: PMC4581591.
  • Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang do W, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, StÄ™pieÅ„ E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15;31(6):933-9. PubMed PMID: 25388151; PubMed Central PMCID: PMC4375401.
  • Nedelska Z, Schwarz CG, Boeve BF, Lowe VJ, Reid RI, Przybelski SA, Lesnick TG, Gunter JL, Senjem ML, Ferman TJ, Smith GE, Geda YE, Knopman DS, Petersen RC, Jack CR Jr, Kantarci K. White matter integrity in dementia with Lewy bodies: a voxelbased analysis of diffusion tensor imaging. Neurobiol Aging. 2015 Jun;36(6):2010-7. PubMed PMID: 25863527; PubMed Central PMCID: PMC4433563.
  • Chiang GC, Cruz Hernandez JC, Kantarci K, Jack CR Jr, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution. AJNR Am J Neuroradiol. 2015 Sep;36(9):1635-41. PubMed PMID: 26228889; PubMed Central PMCID: PMC4729288.
  • Weissgerber TL, Milic NM, Turner ST, Asad RA, Mosley TH Jr, Kardia SL, Hanis CL, Garovic VD. Uric Acid: A Missing Link Between Hypertensive Pregnancy Disorders and Future Cardiovascular Disease?. Mayo Clin Proc. 2015 Sep;90(9):1207-16. PubMed PMID: 26260220; PubMed Central PMCID: PMC4567408.
  • Scantlebury DC, Kane GC, Wiste HJ, Bailey KR, Turner ST, Arnett DK, Devereux RB, Mosley TH Jr, Hunt SC, Weder AB, Rodriguez B, Boerwinkle E, Weissgerber TL, Garovic VD. Left ventricular hypertrophy after hypertensive pregnancy disorders. Heart. 2015 Oct;101(19):1584-90. PubMed PMID: 26243788; PubMed Central PMCID: PMC4568146.
  • Miller VM, Rocca WA, Faubion SS. Sex Differences Research, Precision Medicine, and the Future of Women's Health. J Womens Health (Larchmt). 2015 Dec;24(12):969-71. PubMed PMID: 26325362; PubMed Central PMCID: PMC4683561.
  • Mielke MM, Milic NM, Weissgerber TL, White WM, Kantarci K, Mosley TH, Windham BG, Simpson BN, Turner ST, Garovic VD. Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders. Circ Cardiovasc Qual Outcomes. 2016 Jan;9(1):S70-6. PubMed PMID: 26908863; PubMed Central PMCID: PMC4770570.
  • Turco AE, Lam W, Rule AD, Denic A, Lieske JC, Miller VM, Larson JJ, Kremers WK, Jayachandran M. Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. J Extracell Vesicles. 2016;5:29642. PubMed PMID: 26837814; PubMed Central PMCID: PMC4737715.
  • Weissgerber TL, Milic NM, Milin-Lazovic JS, Garovic VD. Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia: A Systematic Review and Meta-Analysis. Hypertension. 2016 Feb;67(2):415-23. PubMed PMID: 26711737; PubMed Central PMCID: PMC4713258.
  • Miller VM, Lahr BD, Bailey KR, Hodis HN, Mulvagh SL, Jayachandran M. Specific cell-derived microvesicles: Linking endothelial function to carotid artery intima-media thickness in low cardiovascular risk menopausal women. Atherosclerosis. 2016 Mar;246:21-8. PubMed PMID: 26752689; PubMed Central PMCID: PMC4764461.
  • White WM, Mielke MM, Araoz PA, Lahr BD, Bailey KR, Jayachandran M, Miller VM, Garovic VD. A history of preeclampsia is associated with a risk for coronary artery calcification 3 decades later. Am J Obstet Gynecol. 2016 Apr;214(4):519.e1-519.e8. PubMed PMID: 26874301; NIHMSID: 759365.
  • An MRI-based atlas for correlation of imaging and pathologic findings in Alzheimer's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. NIHMSID: 758479.


  • Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A. Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2016 Feb 12;7:10762. PubMed PMID: 26867975; PubMed Central PMCID: PMC4754347.
  • Dunaif A. Perspectives in Polycystic Ovary Syndrome: From Hair to Eternity. J Clin Endocrinol Metab. 2016 Mar;101(3):759-68. PubMed PMID: 26908109; PubMed Central PMCID: PMC4803161.
  • Torchen LC, Idkowiak J, Fogel NR, O'Neil DM, Shackleton CH, Arlt W, Dunaif A. Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2016 Mar 18;PubMed PMID: 26990942.
  • Torchen LC, Kumar A, Kalra B, Savjani G, Sisk R, Legro RS, Dunaif A. Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome. Fertil Steril. 2016 Apr 1;PubMed PMID: 27042970; NIHMSID: 771105.
  • Bethea CL, Reddy AP, Flowers M, Shapiro RA, Colman RJ, Abbott DH, Levine JE. High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 3;58:71-80. PubMed PMID: 25542371; PubMed Central PMCID: PMC4339406.
  • Dubois SL, Acosta-Martínez M, DeJoseph MR, Wolfe A, Radovick S, Boehm U, Urban JH, Levine JE. Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons. Endocrinology. 2015 Mar;156(3):1111-20. doi: 10.1210/en.2014-1851. Epub 2014 Dec 29. PubMed PMID: 25545386; PubMed Central PMCID: PMC4330313.
  • Nicol LE, O'Brien TD, Dumesic DA, Grogan T, Tarantal AF, Abbott DH. Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys. PLoS One. 2014 Sep 10;9(9):e106527. doi: 10.1371/journal.pone.0106527. eCollection 2014. PubMed PMID: 25207967; PubMed Central PMCID: PMC4160158.
  • Torchen LC, Fogel NR, Brickman WJ, Paparodis R, Dunaif A. Persistent apparent pancreatic beta-cell defects in premenarchal PCOS relatives. J Clin Endocrinol Metab. 2014;99(10):3855-62. doi: 10.1210/jc.2014-1474. PubMed PMID: 25029420; PubMed Central PMCID: PMC4184072.
  • Liu DM, Torchen LC, Sung Y, Paparodis R, Legro RS, Grebe SK, Singh RJ, Taylor RL, Dunaif A. Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome. Hum Reprod. 2014;29(12):2764-72. doi: 10.1093/humrep/deu282. PubMed PMID: 25336708; PubMed Central PMCID: PMC4227582.


  • Hong JY, Naliboff B, Labus JS, Gupta A, Kilpatrick LA, Ashe-McNalley C, Stains J, Heendeniya N, Smith SR, Tillisch K, Mayer EA. Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation. Neurogastroenterol Motil. 2016 Jan;28(1):127-38. PubMed PMID: 26526698; NIHMSID: 726144.
  • Jarcho JM, Feier NA, Labus JS, Naliboff B, Smith SR, Hong JY, Colloca L, Tillisch K, Mandelkern MA, Mayer EA, London ED. Placebo analgesia: Self-report measures and preliminary evidence of cortical dopamine release associated with placebo response. Neuroimage Clin. 2016;10:107-14. PubMed PMID: 26759785; PubMed Central PMCID: PMC4683423.
  • Moussaoui N, Larauche M, Biraud M, Molet J, Million M, Mayer E, Taché Y. Limited Nesting Stress Alters Maternal Behavior and In Vivo Intestinal Permeability in Male Wistar Pup Rats. PLoS One. 2016;11(5):e0155037. PubMed PMID: 27149676; PubMed Central PMCID: PMC4858303.
  • Mahurkar S, Polytarchou C, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Genomewide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome. Neurogastroenterol Motil. 2016 Mar;28(3):410-22. PubMed PMID: 26670691; PubMed Central PMCID: PMC4760882.
  • Gupta A, Labus J, Kilpatrick LA, Bonyadi M, Ashe-McNalley C, Heendeniya N, Bradesi S, Chang L, Mayer EA. Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females. Brain Struct Funct. 2016 Apr;221(3):1667-79. PubMed PMID: 25630611; PubMed Central PMCID: PMC4573367.
  • Park SH, Videlock EJ, Shih W, Presson AP, Mayer EA, Chang L. Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity. Neurogastroenterol Motil. 2016 Apr 8;PubMed PMID: 27061107; NIHMSID: 765911.
  • Holschneider DP, Guo Y, Mayer EA, Wang Z. Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats. Neurobiol Stress. 2016 Jun 1;3:8-22. PubMed PMID: 26751119; PubMed Central PMCID: PMC4700548.
  • Videlock EJ, Shih W, Adeyemo M, Mahurkar-Joshi S, Presson AP, Polytarchou C, Alberto M, Iliopoulos D, Mayer EA, Chang L. The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression. Psychoneuroendocrinology. 2016 Jul;69:67-76. PubMed PMID: 27038676.


  • Nelson AE, Golightly YM, Renner JB, Schwartz TA, Liu F, Lynch JA, Gregory JS, Aspden RM, Lane NE, Jordan JM. Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project. J Rheumatol. 2016 Feb;43(2):405-10. PubMed PMID: 26669914; PubMed Central PMCID: PMC4738023.
  • Katzman WB, Vittinghoff E, Kado DM, Lane NE, Ensrud KE, Shipp K. Thoracic kyphosis and rate of incident vertebral fractures: the Fracture Intervention Trial. Osteoporos Int. 2016 Mar;27(3):899-903. PubMed PMID: 26782685.
  • Wise BL, Liu F, Kritikos L, Lynch JA, Parimi N, Zhang Y, Lane NE. The association of distal femur and proximal tibia shape with sex: The Osteoarthritis Initiative. Semin Arthritis Rheum. 2016 Mar 3;PubMed PMID: 27039962; NIHMSID: 765561.
  • An H, Marron JS, Schwartz TA, Renner JB, Liu F, Lynch JA, Lane NE, Jordan JM, Nelson AE. Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage. 2016 Apr;24(4):640-6. PubMed PMID: 26620089; PubMed Central PMCID: PMC4799754.
  • Skou ST, Wise BL, Lewis CE, Felson D, Nevitt M, Segal NA, Multicenter Osteoarthritis Study Group. Muscle strength, physical performance and physical activity as predictors of future knee replacement: a prospective cohort study. Osteoarthritis Cartilage. 2016 Apr 9;PubMed PMID: 27066879; NIHMSID: 776727.
  • Dai W, Zhang H, Zhong Z, Jiang L, Chen H, Lay Y, Kot A, Ritchie R, Lane N, Yao W. β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes. Cinical Orthopaedic and Related Research. Aug 2015. 473(8):2495-504. Doi:10.1007/s11999-015-4246-5. PMID:25822452 PMCID:4488193.
  • Wise BL, Niu J, Guermazi A, Liu F, Heilmeier U, Ku E, Lynch JA, Zhang Y, Felson DT, Kwoh CK, Lane NE. Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease — data from the Osteoarthritis Initiative. Osteoarthiris Cartilage 2016 Aug. doi: 10.1016/j.joca.2016.08.002 PMID: 27539891.
  • Wise BL, Kritikos L, Lynch JA, Liu F, Parimi P, Luker Tileston K, Nevitt N, Lane NE. Proximal Femur Shape Differs Between Subjects with Lateral and Medial Knee Osteoarthritis and Controls: The Osteoarthritis Initiative. Osteoarthritis and Cartilage. 2014 Dec;22(12):2067-73. PMID:25194496. PMCID:PMC4252863.
  • Jepsen KJ, Lane NE, Healey JH, Tosi LL. Editorial Comment: Symposium: Sex Differences in Musculoskeletal Disease and Science. Clin Orthop Relat Res. 2015 Jun 16. PMID: 26077610.


  • Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Lindstrom RC, MacLean PS. Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol. 2016;7:32. PubMed PMID: 26903882; PubMed Central PMCID: PMC4748045.
  • Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan;39(1):39-42. PubMed PMID: 26223240; PubMed Central PMCID: PMC4686845.
  • MacLean PS, Higgins JA, Giles EG, Sherk V, Jackman MR. The role for adipose tissues in weight regain. Obesity Rev 16 Suppl 1:45-54, 2015. PMID: 25614203 PMCID: 4371661 DOI:10.1111/obr.12255
  • Bessesen, DB, Cox-York, KA, Hernandez, TL, Erickson, DB, Wang, H, Jackman MR, VanPelt, RE. Postprandial triglycerides and adipose tissue storage of dietary fatty acids: impact of menopause and estradiol. Obesity (Silver Spring). 2015 23:145-53.
  • Hernandez, TL, Bessesen, DH, Cox-York, KA, Erickson, CB, Law, CK, Anderson, M, Wang, H, Jackman, MR, Van Pelt, RE. Femoral lipectomy increases postprandial lipemia in Women. Am J Physiol Endocrinol Metab. 2015 May 12. PMID: 25968576 PMCID: PMC4490330 DOI: 10.1152/aipendo,00080.2015
  • Shea KL, Gavin KM, Melanson EL, Gibbons E, Stavros A, Wolfe P, Kittelson JM, Vondracek SF, Schwartz RS, Wierman ME, Kohrt WM. Body composition and bone mineral density after ovarian hormone suppression with or without estradiol treatment. Menopause, 2015 Mar 16. PMID: 25783468 PMCID: 4760356 DOI:10.1097/GME.0000000000000430.
  • Van Pelt RE, Gavin KM, Kohrt WM. Regulation of body composition and bioenergetics by estrogens. Endocrinology and Metabolism Clinics of North America, 2015. PMID: 26316249 PMCID: PMC4555869 DOI: 10.1016/j.ecl.2015.05.011.


  • Allen AM, McRae-Clark AL, Carlson S, Saladin ME, Gray KM, Wetherington CL, McKee SA, Allen SS. Determining menstrual phase in human biobehavioral research: A review with recommendations. Exp Clin Psychopharmacol. 2016 Feb;24(1):1-11. PubMed PMID: 26570992; PubMed Central PMCID: PMC4821777.
  • Swalve N, Smethells JR, Carroll ME. Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats. Psychopharmacology (Berl). 2016 Mar;233(6):1005-13. PubMed PMID: 26685990; PubMed Central PMCID: PMC4761341.
  • Swalve N, Smethells JR, Zlebnik NE, Carroll ME. Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine. Pharmacol Biochem Behav. 2016 Jun;145:17-23. PubMed PMID: 27003832; PubMed Central PMCID: PMC4864132.
  • Swalve N, Smethells JR, Carroll ME. Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline. Behav Brain Res. 2016 Jul 15;308:46-52. PubMed PMID: 27091301; PubMed Central PMCID: PMC4877227.
  • Hinderaker K, Allen AM, Hatsukami D, Allen SS. Effect of oral contraceptive use on smoking-related symptomatology during short-term smoking abstinence. (2014). Addictive Behaviors; 23: 148-151.
  • Smethells JR, Swalve NL Carroll ME (2015) Reducing impulsive choice for cocaine in female rats using atomoxetine and progesterone. Psychopharmacology (Berl) 2016 Aug 233(15-16)2999-3008. Doi: 10.1007/s00213. PMID: 27325394 PMCID: PMC4935598.


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Recent News

ORWH SCOR Program Director Dr. Sherry McKee featured in the American Psychological Association Newsletter (PDF - 2.4 MB)

ORWH Selects Third Round of Specialized Centers of Research on Sex Differences

Eleven new or continuing SCOR on Sex Differences awards have been announced by ORWH. SCOR is an innovative interdisciplinary research program, focusing on sex differences and major medical conditions affecting women. Potential funding for these new or competing SCORs will total over $11 million per year for 5 years contingent upon available funding and is supported by ORWH and six other institutes at NIH.

The SCOR centers were selected on the basis of having at least three highly integrated, synergistic research projects that explore an important issue related to sex/gender health differences through interdisciplinary approaches. The programmatic management of each SCOR resides in the co-funding NIH institutes, and ORWH monitors progress in advancing sex differences research across the centers and coordinates the inter-SCOR interactions. The centers are co-funded by the National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Diabetes, Digestive and Kidney Diseases, the National Institute on Drug Abuse, the National Institute of Mental Health, and the U.S. Food and Drug Administration.

One of the major goals of the new NIH strategic plan, Moving into the Future with New Dimensions and Strategies: A Vision for 2020 for Women's Health Research, is "to increase sex differences research in basic science studies," and it is hoped that the expansion of the SCOR Centers will help achieve this goal. The research areas of the 11 centers include musculoskeletal diseases, vascular dysfunction and cognitive decline, depression, reproductive health, metabolic disorders, pain and urinary tract infections (UTI) while incorporating a sex /gender perspective. Each of the SCOR's individual projects must be related by a common theme, encompassing basic and clinical research paving the way for translation to clinical practice. An administrative unit at each institution oversees coordination of the individual projects.

"ORWH views these 11 SCOR institutions as instrumental to advancing the understanding of the role of sex differences in health and disease. The unique structure of the SCORs with inter related, basic and clinical projects designed with an interdisciplinary approach and supported through an administrative core were created to drive the understanding of sex/gender factors that will translate into clinical care and practice" said Janine Austin Clayton, M.D., director, ORWH.