R56 is a recognized activity code under which applications can be funded at NIH and that will allow Institutes and Centers (ICs) to submit to participating OD Offices nominations for research proposals. The R56 program is a collaborative effort in which offices within the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) send out a single internal announcement to call for applications and fund applications independently. For fiscal years (FYs) 2014 and 2015, ORWH, the Office of AIDS Research (OAR), and the Office of Behavioral and Social Sciences Research collaborated. In FYs 2016 and 2017, ORWH, OAR, and the Office of Disease Prevention – Office of Dietary Supplements have partnered together.

The objective of the R56 program is to implement a flexible funding opportunity that allows program offices within DPCPSI to partner with NIH ICs to provide funds for meritorious Type 1 or Type 2 research applications (A0, A1) that are highly relevant to the mission of the participating OD Offices and that fall just outside the IC pay line. The R56 program allows a principal investigator (PI) to further develop his or her research proposal for a new, competing renewal, or resubmission application. This funding offers the investigator an opportunity to improve the research proposal significantly so that the submission or resubmission application will succeed in a highly competitive peer review and fiscal environment. In addition, the use of the R56 activity code can potentially enhance research in targeted areas, such as the influence of sex and gender on health and disease.

Projects funded through the R56 program in FY14 and FY15 include:

Project Title


Issuing IC

Mechanisms of Macrophage Activation and Function in Scleroderma

Patricia A. Pioli


Imaging data re-analysis for cocaine addiction

Ze Wang


Cost-Effectiveness and Efficacy of Computerized Therapy for Depression and Drug Use

Suzette V Glasner-Edwards


A Videoconferencing Tobacco Cessation Research Study (Victory)

Sun Seog Kim


Community-Clinic Partnership to Promote Physical Activity in South Asian Women

Namratha Kandula



Probiotic Analgesia for Pelvic Pain

David J. Klumpp


Toxicokinetics and metabolic disruption actions of the flame retardant mixture FM

Heather B. Patisaul


Sex differences in myocardial ischemia/reperfusion injury

Arthur P. Arnold


Creatine Monohydrate Supplementation in Methamphetamine-Using Female

Perry Franklin Renshaw


Corticotropin-Releasing Factor/Serotonergic Interactions

Rita Valentino


Immune modulation of hypertension

Kathryn L. Sandberg


Impact of Prenatal Hypoxia on Mitochondrial Function of Offspring Hearts

Loren P. Thompson



The interaction of varenicline, ethanol, and CNS development

Dustin W. DuBois


Stress and Decision-Making in Older Persons: Toward a Neurobehavioral Phenotype

Natalie L. Denburg


Circulating MicroRNAs and TLR8 Activation in Chronic Pain

Asma Khan


The Female Urinary Microbiome and Urinary Incontinence

Linda Brubaker


Improving Heart Transplant Allocation to Reduce High Waitlist Mortality in Women

Eileen Michelle Hsich


Neurodevelopmental Features of Sexual Dimorphism in Pediatric Psychopathology

Manpreet K Singh


Altering the physical microenvironment and enhancing lipid availability for in vitro follicle and oocyte development

Nucharin Songsasen


Mitochondrial function and insulin sensitivity in African American women

James DeLany


Estradiol and Hippocampal Development

Margaret M. McCarthy