R56 is a recognized activity code under which applications can be funded at NIH and that will allow Institutes and Centers (ICs) to submit to participating OD Offices nominations for research proposals. The R56 program is a collaborative effort in which offices within the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) send out a single internal announcement to call for applications and fund applications independently. For fiscal years (FYs) 2014 and 2015, ORWH, the Office of AIDS Research (OAR), and the Office of Behavioral and Social Sciences Research collaborated. In FYs 2016 and 2017, ORWH, OAR, and the Office of Disease Prevention – Office of Dietary Supplements have partnered together.

The objective of the R56 program is to implement a flexible funding opportunity that allows program offices within DPCPSI to partner with NIH ICs to provide funds for meritorious Type 1 or Type 2 research applications (A0, A1) that are highly relevant to the mission of the participating OD Offices and that fall just outside the IC pay line. The R56 program allows a principal investigator (PI) to further develop his or her research proposal for a new, competing renewal, or resubmission application. This funding offers the investigator an opportunity to improve the research proposal significantly so that the submission or resubmission application will succeed in a highly competitive peer review and fiscal environment. In addition, the use of the R56 activity code can potentially enhance research in targeted areas, such as the influence of sex and gender on health and disease.

Projects funded through the R56 program in FY14 and FY15 include:

Project Title

PI

Issuing IC

Mechanisms of Macrophage Activation and Function in Scleroderma

Patricia A. Pioli

NIAMS

Imaging data re-analysis for cocaine addiction

Ze Wang

NIDA

Cost-Effectiveness and Efficacy of Computerized Therapy for Depression and Drug Use

Suzette V Glasner-Edwards

NIDA

A Videoconferencing Tobacco Cessation Research Study (Victory)

Sun Seog Kim

NIDA

Community-Clinic Partnership to Promote Physical Activity in South Asian Women

Namratha Kandula

 

NIDDK

Probiotic Analgesia for Pelvic Pain

David J. Klumpp

NIDDK

Toxicokinetics and metabolic disruption actions of the flame retardant mixture FM

Heather B. Patisaul

NIEHS

Sex differences in myocardial ischemia/reperfusion injury

Arthur P. Arnold

NHLBI

Creatine Monohydrate Supplementation in Methamphetamine-Using Female

Perry Franklin Renshaw

NIDA

Corticotropin-Releasing Factor/Serotonergic Interactions

Rita Valentino

NIMH

Immune modulation of hypertension

Kathryn L. Sandberg

NHLBI

Impact of Prenatal Hypoxia on Mitochondrial Function of Offspring Hearts

Loren P. Thompson

 

NHLBI

The interaction of varenicline, ethanol, and CNS development

Dustin W. DuBois

NIAAA

Stress and Decision-Making in Older Persons: Toward a Neurobehavioral Phenotype

Natalie L. Denburg

NIA

Circulating MicroRNAs and TLR8 Activation in Chronic Pain

Asma Khan

NIDCR

The Female Urinary Microbiome and Urinary Incontinence

Linda Brubaker

NIDDK

Improving Heart Transplant Allocation to Reduce High Waitlist Mortality in Women

Eileen Michelle Hsich

NHLBI

Neurodevelopmental Features of Sexual Dimorphism in Pediatric Psychopathology

Manpreet K Singh

NIMH

Altering the physical microenvironment and enhancing lipid availability for in vitro follicle and oocyte development

Nucharin Songsasen

OD

Mitochondrial function and insulin sensitivity in African American women

James DeLany

NIDDK

Estradiol and Hippocampal Development

Margaret M. McCarthy

NINDS