|
WEDNESDAY MAY
5, 1999
| 8:30 - 8:45 |
WELCOME
Vivian W. Pinn, MD, Director, Office
of Research on Women's Health, NIH
Ruth L. Kirschstein, MD, Deputy Director, NIH
Janet Woodcock, MD, Director, Center for Drug Evaluation and
Research,
FDA
|
| 8:45 - 9:15 |
PLENARY
Combining
Sex Based Biology and Pharmacogenetics to Reduce Serious Adverse
Events in Women - Raymond Woosley, MD, PhD, Georgetown University
|
| 9:15 - 11:00 |
PANEL: PHARMACODYNAMIC DIFFERENCES
Moderator: Art Atkinson, MD, Warren Grant Magnuson Clinical
Center, National Institutes of Health
|
| 9:15-9:45 |
Treatment
of Acute Myocardial Infarction in Women
Alexandria J. Lansky, MD,
Washington Cardiovascular Research Foundation |
| 9:45-10:15 |
Sex
Differences in Pain and Analgesia
M. A. Ruda, PhD, National Institute
of Dental and Craniofacial Research, National Institutes of Health |
| 10:15- 10:45 |
Pharmacologic
Treatment of Epilepsy in Pregnancy
Katharine Wenstrom, MD, University
of Alabama |
| 10:45-11:00 |
Questions
and Discussion |
| 11:00-11:15 |
BREAK |
| 11:15-12:50 |
PANEL:
PHARMACOKINETIC DIFFERENCES
Moderator: Mary J. Berg, PharmD, University of Iowa |
| 11:15-11:45 |
Sex/Gender
Differences in Pharmacokinetics
Leslie Z. Benet, MD, University
of California, San Francisco |
| 11:45-12:15 |
Drug
Interactions: Are They Affected by Sex/Gender?
Catherine White, PhD, University
of Georgia |
| 12:15-12:35 |
Time
Dependent Variations in the Kinetics and Actions of Medications
Gaston Labrecque, PhD,
Laval University |
| 12:15-12:35 |
Chronopharmacokinetics
Gaston Labrecque, PhD, Laval
University |
| 12:35-12:50 |
Questions
and Discussion |
| 12:50-2:00 |
LUNCH
(on your own) |
| 2:00-2:10 |
INTRODUCTORY
COMMENTS
Richard A. Millstein, JD, Deputy Director, National Institute
on Drug Abuse,NIH |
| 2:10-3:45 |
PANEL:
PHARMACOGENETIC DIFFERENCES
Moderator: Henry Lewis III, PhD, Florida A&M University |
| 2:10-2:40 |
Pharmacogenetic
Differences: Phase I Drug Metabolizing Enzymes
Gail Anderson, PhD, University
of Washington |
| 2:40-3:10 |
Sex
Differences in Pharmacogenetics: Phase II Enzymes
Richard Weinshilboum, MD,
Mayo Clinic Medical Center |
| 3:10-3:30 |
Pharmacodynamic
Polymorphisms: Contribution to Variability in Drug Response?
Darrell Abernethy, MD, PhD,
National Institute on Aging, NIH |
| 3:30-3:45 |
Questions
and Discussion |
| 3:45-4:00 |
BREAK |
| 4:00-5:45 |
PANEL:
HORMONAL INFLUENCES
Moderator: Linda Niessen, DMD, MPH, MPP, Baylor College of Dentistry |
| 4:00-4:30 |
Estrogen
Receptors: New Drugs, New Insights
Donald McDonnell, PhD, Duke
University |
| 4:30-5:00 |
Hormones
and Drug Interactions: A CNS Perspective
Patricia Kroboth, PhD, University
of Pittsburgh |
| 5:00-5:30 |
Menstrual
Cycle, Disease and Pharmacotherapy: Chronobiologic and Investigative
Issues
Michael Smolensky, PhD, University
of Texas |
| 5:30-5:45 |
Questions
and Discussion |
| 5:45-7:00 |
NETWORKING
RECEPTION
Lister Hill Foyer |
THURSDAY,
MAY 6, 1999
| 8:30 - 9:00 |
WELCOME
Marietta Anthony, PhD, Director, Research Programs, Office of
Research on Women's Health, NIH
Jonca Bull, MD, Acting Deputy Director, Office of Women's Health,
FDA
PLENARY
Involvement
of the Multidrug Transporter in Absorption, Distribution and
Excretion of Drugs
Michael Gottesman, MD, Deputy
Director for Intramural Research, National Institutes of Health
|
| 9:00-11:45 |
PANEL:
PREDICTABILITY
Moderator: Robert
Taylor, MD, PhD, Howard University
|
| 9:00-9:30 |
Sex Differences in Relationships Between Pharmacokinetics
and Pharmacodynamics
William
Jusko, PhD, State University of New York at Buffalo |
| 9:30-9:55 |
The
Pittsburgh Cocktail: An Experimental Paradigm to Investigate the
Selective Regulation of Individual Cytochrome P450 (CYP) Enzymes
in Humans
Robert Branch, MD, University of
Pittsburgh |
| 9:55-10:10 |
BREAK |
| 10:10-10:40 |
Relation
of Genotype and Phenotype to Clinical Outcomes
Maureen Cronin, PhD, Protogene
and David Flockhart, MD, PhD, Georgetown University |
| 10:40-11:05 |
Computational
biology in Cardiovascular Medicine: Insights into Gene Function
and Drug Action
Thomas J. Colatsky, PhD,
Physiome Sciences, Inc. |
| 11:05-11:30 |
Sex
Differences in Aging and Alzheimer’s Disease
Gillian Einstein, PhD, Duke
University |
| 11:30-11:45 |
Questions
and Discussion |
| 11:45-12:30 |
CLOSING
PANEL
Moderator: Rosalie Sagraves, PharmD, University
of Illinois at Chicago
PANEL DISCUSSION
Bert
Spilker, PhD, MD, Senior Vice President, Scientific and
Regulatory Affairs, Pharmaceutical Research and Manufacturers
of America
Roger Williams, MD, The Center
for Drug Evaluation and Research, FDA
Janice B. Schwartz, MD, Professor, Northwestern University
Harold Slavkin, DDS, Director,
National Institute of Dental and Craniofacial Research, NIH
|
| 12:30-12:45 |
Questions
and Discussion |
| 12:45 |
CONCLUDING REMARKS
Vivian W. Pinn, MD, Director, Office of Research on Women's Health,
NIH |
WORKSHOP
COORDINATORS: Marietta Anthony, PhD, Office of Research
on Women's Health, NIH and Mary J. Berg, PharmD, University of Iowa
|
